The harmful actions that are examined in Islamic jurisprudence under the no-harm rule are one of the challenges that may be realized in the field of cryptocurrencies in various ways, while briefly reviewing the no-harm rule and adopting a selected perspective on its provisions, it has examined several cases in the issue of its scope, and then raised and examined the problems that may be faced by cryptocurrency market activists from this rule. The results show that; lack of awareness of the infrastructure and hardware capabilities of cryptocurrencies, as well as the principles governing their transactions, are the reasons for many of the losses incurred by traders, which may prevent the rule of no-harm from being applied to this market. The existence of unlimited fluctuations, hacking of user accounts, and the inability to recover in case of sending the wrong information are some of the things that happen as a result of this ignorance, although in the meantime, there are dangers that threaten Iranian users in particular, Regarding the negative environmental consequences of this emerging phenomenon, it should also be said that if the losses from mining cryptocurrencies can be minimized and reduced to a reasonable level by applying methods such as the use of renewable energy, optimizing miner hardware, properly recycling electronic components, recycling the heat generated, using more efficient coolers with less water consumption, and avoiding the use of flare gas, we can ensure that the no-harm rule does not apply in the mining industry.